01
Assay Development, Optimization & Troubleshooting
Design, refinement, and systematic rescue of biochemical, cell-based, and binding assays — from first principle to validated performance.
Life-science consulting · PhD-led
Complex Science.
Solved.
Expert scientific consulting that transforms difficult R&D challenges into clear, actionable solutions.
- Potency
- EC50 · IC50 · KD
- Method
- Dose–response
- Quality
- S/N ≥ 10
- Fit
- R² ≥ 0.99
01 — Problems we solve
The scientific problems that stall programs.
Behind every delayed milestone is a specific, solvable scientific problem. These are the ones we are called in for most.
01
An assay that works in one pair of hands — and no one else’s.
We isolate the hidden variables, rebuild the protocol around them, and make performance transferable.
02
A promising antiviral hit stalls between screening and candidate selection.
We design the counter-screens and mechanism studies that separate real signal from artifacts.
03
Data you can’t interpret with confidence — and a decision that can’t wait.
We re-frame the experiment, stress-test the statistics, and tell you what the data actually supports.
04
An investor’s technical question your team can’t answer yet.
We pressure-test the science and build the evidence narrative before the diligence call, not after.
05
A critical experiment keeps failing for reasons nobody can pin down.
We troubleshoot systematically — reagents, biology, protocol, operator — until the failure has a name.
06
R&D momentum lost to unclear protocols, SOPs, and workflows.
We document and streamline the work so results survive handoffs, hires, and site transfers.
02 — Services
Eleven ways we solve them.
From a single failing assay to a full fractional R&D function — every service is delivered by a PhD-level scientist.
02
Bioassay Strategy & Assay Rescue
Root-cause analysis for assays that drift, fail to transfer, or refuse to reproduce — and a strategy that makes them decision-grade.
03
Molecular Biology & Virology Consulting
Deep technical guidance across molecular cloning, viral systems, and cell culture models, grounded in hands-on laboratory experience.
04
Antiviral Drug-Discovery Support
Target-to-hit support for antiviral programs: screening cascades, counter-screens, mechanism studies, and candidate prioritization.
05
Experimental Design & Data Interpretation
Rigorous study design, statistical framing, and clear interpretation that turns ambiguous readouts into confident decisions.
06
Scientific Due Diligence & Technical Assessment
Independent, evidence-based evaluation of platforms, pipelines, and datasets for investors, partners, and acquirers.
07
Fractional Scientific / R&D Advisory
Embedded senior scientific leadership on a fractional basis — strategy, prioritization, and mentorship without a full-time hire.
08
SOP, Protocol & Workflow Development
Clear, transferable documentation: SOPs, protocols, and workflows that make results reproducible across people and sites.
09
Biotech Startup Scientific Advisory
Scientific co-piloting for founders — from validating the core experiment to building a credible R&D narrative for investors.
10
Laboratory Workflow Consulting
Practical optimization of lab operations: throughput, handoffs, quality checkpoints, and the elimination of hidden bottlenecks.
11
Scientific Training
Targeted training for scientific teams — assay best practices, data literacy, and experimental discipline that sticks.
03 — Why BioSolve
Precision is the difference.
BioSolve operates at the intersection of science, strategy, and problem-solving — where hard R&D questions get rigorous, actionable answers.
01
PhD-level leadership
Every engagement is led directly by a PhD scientist — never handed off to junior generalists or account layers.
02
Pharma & biotech R&D depth
Extensive hands-on experience inside pharmaceutical and biotechnology R&D programs, from bench to candidate selection.
03
Bench-to-boardroom fluency
We speak both languages: the experimental detail your scientists need and the strategic clarity your stakeholders expect.
04
Root cause, not workarounds
We solve the underlying scientific problem — so the fix holds when the assay, the team, or the program scales.
04 — How we work
A disciplined path from problem to answer.
No black boxes, no boilerplate reports. A transparent, scientific method applied to your specific challenge.
- 01
Discover
A focused deep-dive into your scientific challenge: the data you have, the decisions you face, and what “solved” looks like.
- 02
Diagnose
We identify the true bottleneck — biological, technical, or procedural — and separate signal from noise.
- 03
Design
A concrete plan: experiments, controls, protocols, and decision criteria, sequenced for the fastest defensible answer.
- 04
Deliver
Clear, actionable output — interpreted results, documentation, and recommendations your team can execute immediately.
Fig. 01 — Dose–response, decision-grade
05 — Expertise
Deep where it matters.
Not generalist consulting — specialist depth in the experimental sciences that drive biotech and pharmaceutical R&D.
Assay development & optimization
Biochemical · Cell-based · Binding · Kinetics
Bioassay strategy & assay rescue
Reproducibility · Transfer · Validation · Troubleshooting
Molecular biology & virology
Viral systems · Cloning · Cell models · Expression
Antiviral drug discovery
Screening cascades · Counter-screens · MoA · Hit-to-lead
Experimental design & data interpretation
Study design · Statistics · Dose–response · Decision criteria
06 — Industries served
- 01Biotech Startups
- 02Pharmaceutical Companies
- 03CROs
- 04Academic Spinouts
- 05Laboratories
- 06Investors & VCs
- 07Life-Science Organizations
Bench-led · PhD-driven
07 — Scientific leadership
Founded and led by a PhD scientist.
BioSolve USA was founded by a PhD-level scientist with extensive biotechnology and pharmaceutical R&D experience — a career spent developing assays, advancing antiviral discovery programs, and troubleshooting the experiments that everyone else had given up on.
“Hard scientific problems don’t need more noise. They need precision — and someone who has solved them at the bench before.”
- PhD-level scientific leadership on every engagement
- Extensive pharmaceutical & biotechnology R&D experience
- Deep expertise in assay development and bioassay strategy
- Virology and antiviral drug-discovery background
- Experimental troubleshooting at bench and program level
08 — Engagement models
Senior science, structured your way.
Three ways to bring PhD-level scientific problem-solving into your program — matched to the shape of your challenge.
Project-Based Engagement
A defined scientific problem with a defined deliverable — assay rescue, due diligence, protocol development — scoped, scheduled, and solved.
Best for
Teams facing one hard, bounded problem.
Fractional Scientific Advisory
Ongoing senior R&D leadership on a retainer basis: strategy, experimental review, team mentorship, and investor-ready scientific narrative.
Best for
Startups and growing teams that need a CSO-level brain, fractionally.
On-Demand Expert Consultation
Rapid, targeted sessions to pressure-test an experiment, interpret a dataset, or unblock a stalled decision — booked as needed.
Best for
Scientists and executives who need an expert answer now.
09 — FAQ
Questions, answered precisely.
The essentials before we talk. Anything more specific is best discussed directly about your challenge.
10 — Contact
Discuss your scientific challenge.
Tell us what you are working on and where it is stuck. You will hear back from a scientist — not a sales team.
- Confidential by default — NDAs welcome
- Response within one business day
- A clear, fixed proposal before any work begins
BioSolve USA · www.biosolveusa.com